October 26, 2026
Lyme serology has two clinical blind spots
Early Lyme tests may be negative, while antibodies can remain positive long after successful treatment.
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October 25, 2026
The limits of a 24-hour alteplase window
Late alteplase improves one recovery measure but raises bleeding risk and leaves important timing questions unresolved.
Read briefingOctober 15, 2026
When the study answers the wrong question
GRADE helps distinguish promising research findings from evidence reliable enough to guide clinical decisions.
Read briefingOctober 12, 2026
Lyme disease beyond the bull's-eye rash
Recognise Lyme from expanding rashes or disseminated symptoms, even without a remembered tick bite.
Read briefingOctober 7, 2026
When personality change signals frontotemporal dementia
Family observations and inherited patterns can reveal dementia while everyday abilities remain relatively preserved.
Read briefingSeptember 30, 2026
ALS/NMD is a pattern, not a test
Mixed upper and lower motor neuron signs matter more than any single investigation when ALS is suspected.
Read briefingSeptember 20, 2026
Does paracetamol add to morphine?
Adjunctive intravenous paracetamol may help acute pain, but the trial leaves clinically important uncertainty.
Read briefingSeptember 19, 2026
When polio stops fitting the pattern
Sensory symptoms, symmetry and age-specific incidence challenge an established diagnosis of paralytic polio.
Read briefingSeptember 17, 2026
Back pain before the weakness starts
Spinal epidural abscess can be advanced before fever or neurological deficits appear.
Read briefingSeptember 15, 2026
When anisocoria changes the differential
Light–dark comparison and associated signs help separate benign anisocoria from neurological emergencies.
Read briefingSeptember 14, 2026
Brain death requires a complete assessment
Residual responses, confounders or incomplete testing can prevent a brain death diagnosis despite devastating injury.
Read briefingSeptember 14, 2026
When a negative dipstick misses proteinuria
Proteinuria needs quantification because dipsticks can miss albumin and ACR does not measure all urinary protein.
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