The Clinical Problem Solvers is a global medical education initiative dedicated to enhancing diagnostic reasoning skills among healthcare professionals. Founded in 2018, the platform offers a podcast series that delves into the intricacies of clinical problem-solving through unscripted case discussions, expert interviews, and thematic episodes.

Acute medicine, emergency and rheumatology clinicians get an evolving case of proximal pain and stiffness. Repeat inflammatory markers, morning stiffness, clinical-radiological correlation and serial reassessment help distinguish polymyalgia rheumatica from local hip disease, neurological pathology and elderly-onset rheumatoid arthritis.

Rheumatology, haematology and neurology teams get a complex case linking hypercalcaemia, hilar lymphadenopathy, cryoglobulinaemic vasculitis and progressive demyelinating neuropathy. Longstanding sicca symptoms, monoclonal immunoglobulin and anti-MAG neuropathy challenge an earlier sarcoidosis diagnosis and point towards lymphoma associated with Sjögren’s disease.

Emergency, infectious-diseases and neurology clinicians get a diagnostic-reasoning case involving headache, neck pain, fever, aphasia and focal neurological deficit. It shows how bacterial meningoencephalitis can resemble stroke, produce raised intracranial pressure and cause cerebral infarction through meningitis-associated vascular complications.

Cardiology, neurology and emergency clinicians get a diagnostic-reasoning case in which seizure-like activity represents possible convulsive syncope from malignant arrhythmia. Negative EEG findings, prolonged QTc, stimulant exposure and hypertrophic obstructive cardiomyopathy reinforce the importance of ECG review, rhythm monitoring and physiology-specific management.

Primary-care and service-design teams get a community-facing approach to hypertension management, preventive screening, substance-use care and primary-care access. Trusted locations, walk-in services, culturally concordant teams, patient navigation and reliable follow-up pathways are treated as essential parts of mobile clinical care.

Haematology, oncology and medical-education readers get a structured approach to diffuse retroperitoneal and inguinal lymphadenopathy. The episode links clinical-radiographic mismatch, blood-test diagnoses before biopsy, high-yield tissue sampling, indolent lymphoma and professional boundaries when diagnostic uncertainty affects family.

Critical-care, haematology and infectious-diseases clinicians get a diagnostic reasoning case around ultrahyperferritinaemia, suspected secondary HLH, disseminated herpesvirus infection, cytopenias, liver injury, DIC and shock in an immunosuppressed patient with lupus nephritis. It emphasises red-flag back pain, diagnostic pivots, returning-traveller infection work-up and avoiding anchoring on autoimmune flare.

Acute medicine, rheumatology and orthopaedic teams get an anatomical approach to atraumatic posterior elbow swelling. Preserved movement supports olecranon bursitis over primary joint disease, but cirrhosis, kidney failure and chronic oedema lower the threshold for ultrasound, aspiration and fluid analysis when treatment fails.

Acute-care, neurology and cardiology clinicians get a diagnostic reasoning case beginning with sudden dense right hemiplegia. Intracerebral haemorrhage, multifocal infarcts, a right atrial and pericardial mass and metastatic angiosarcoma reinforce stroke-pathway urgency, review of previous records and the limits of a single negative cytology result.

A professional-development piece for clinicians weighing career choices, burnout, job fit, networking and negotiation. It reframes values as concrete priorities, including flexibility, autonomy, teaching, stability and sustainability, then links those values to offers, trade-offs and contract discussions.