Clinical Problem Solvers Podcast

The Clinical Problem Solvers is a global medical education initiative dedicated to enhancing diagnostic reasoning skills among healthcare professionals. Founded in 2018, the platform offers a podcast series that delves into the intricacies of clinical problem-solving through unscripted case discussions, expert interviews, and thematic episodes.

June 18, 2026

Episode 462 – The Clinical Unknown Series with Lera Novotnaia

Acute-care, neurology and cardiology clinicians get a diagnostic reasoning case beginning with sudden dense right hemiplegia. Intracerebral haemorrhage, multifocal infarcts, a right atrial and pericardial mass and metastatic angiosarcoma reinforce stroke-pathway urgency, review of previous records and the limits of a single negative cytology result.

June 11, 2026

Episode 461: WDx #42: Networking, Negotiating, and Defining Your Values

A professional-development piece for clinicians weighing career choices, burnout, job fit, networking and negotiation. It reframes values as concrete priorities, including flexibility, autonomy, teaching, stability and sustainability, then links those values to offers, trade-offs and contract discussions.

June 2, 2026

Episode 460 – RLR – Abrupt Lightheadedness

Exertional lightheadedness is framed as a perfusion symptom, not just vague dizziness. The case links syncope, new ECG abnormalities, right ventricular strain and saddle pulmonary embolism, with a clear warning against accepting dehydration too early.

May 29, 2026

Episode 459 – Schema Episode: Coagulopathy

Major soft-tissue bleeding after minor trauma plus isolated prolonged activated partial thromboplastin time should change the plan. Recurrent haematomas need coagulation testing, mixing studies and factor assays, while a tense painful forearm with paraesthesia or passive-stretch pain needs immediate surgical escalation.

May 14, 2026

Episode 458 – A Case & The Book – Rabih and Reza discuss with Dr. Daniel Kelmenson, a patient with severe hypoxemia

Severe apparent desaturation after rasburicase is worth choosing when oxygen numbers do not match the bedside picture. It links suspected acute leukaemia, G6PD deficiency, methaemoglobinaemia, co-oximetry and hyperleukocytosis-related pseudohypoxaemia.

May 8, 2026

Episode 457 – The Clinical Unknown Series with Dr. Ravi Singh

Open this first when abdominal distension comes with weight loss, jaundice and oedema. High-protein portal hypertensive ascites, raised JVP with clear lungs, low-voltage ECG with ventricular hypertrophy and protein gap should move the case towards Budd-Chiari syndrome, cardiac amyloidosis and light-chain myeloma.

May 5, 2026

Episode 456 – RLR – A moving target

Atraumatic hip pain that disappears can still be the first visible part of systemic infection. Persistent fever, night sweats, weight loss, oral ulcers, splenomegaly and migratory oligoarthritis make travel and unpasteurised dairy exposure worth asking about.

April 30, 2026

Episode 455 – Spaced Learning Series: Abdominal pain and distension

Right upper quadrant pain with ascites, dyspnoea and weight loss needs two timelines, not a forced single diagnosis. Diagnostic paracentesis matters when fluid is low-SAAG, haemorrhagic, neutrophilic or bilious, especially with suspected secondary bacterial peritonitis or biliary leak.

April 17, 2026

Episode 454: Pulmonary Hypertension

Syncope in pulmonary hypertension is a bad sign, not an incidental symptom. Open this for the bedside traps: a negative CT pulmonary angiogram does not exclude chronic thromboembolic disease, and rapid worsening after vasodilators should raise concern for pulmonary veno-occlusive disease.

April 7, 2026

Episode 453 – RLR – How do the dots connect?

The clue is the mismatch: coffee-ground emesis with little haemodynamic consequence, plus confusion, falls and hyponatraemia. Worth opening first for a clean lesson in reopening the differential, examining the mouth, and spotting subdural haematoma before one abnormal result ends the thinking.

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