Persistent dyspepsia, postprandial fullness or epigastric discomfort should be revisited when weight loss, anaemia, vomiting or upper gastrointestinal bleeding appear. Multiple biopsies and formal staging matter because diffuse gastric cancer can look subtle endoscopically, and cross-sectional imaging alone may miss peritoneal spread.

Basal cell carcinoma rarely metastasises, but slow growth does not mean benign behaviour. Clinically, persistent pearly, bleeding or scar-like lesions need careful risk assessment because infiltrative subtypes extend beyond visible margins and may require specialist surgery rather than routine primary care treatment.

Normal pressure does not exclude glaucoma. Progressive peripheral field loss, disc change and corneal thickness all matter, and asymptomatic patients still need structured assessment because treatment slows irreversible optic neuropathy rather than restoring lost vision.