A specialist neurodevelopmental care update for clinicians supporting patients with Rett syndrome and families. It highlights caregiver observations, communication support, active specialty mapping, rehabilitation input and planned transition from paediatric to adult services when needs evolve over time.

AAN member sections and Synapse communities are presented as year-round routes for neurology learning. Peer Q&A, protocol sharing and career advice can reduce isolated problem-solving when local answers are incomplete.

Recent DOAC use can complicate thrombolysis without stopping the stroke alert. This is a compact guide to treating anticoagulant exposure as a relative contraindication, clarifying drug and last dose early, and documenting a senior risk–benefit discussion for disabling acute ischaemic stroke.

Persistent unilateral weakness, facial droop, speech disturbance or wake-up deficit needs a broad stroke alert process. The key clinical distinction is that activation screens for time-critical assessment; it is not a severity score or proof of acute ischaemic stroke.

Older adults with gait decline, cognitive change and urinary symptoms need more than a remembered triad. The shunting review explains how imaging, temporary CSF drainage response and objective gait measures help frame referral, consent and the real risks of haematoma or low-pressure headache.

Sudden painless monocular visual loss is treated here as acute retinal ischaemia, requiring stroke-style urgency rather than routine outpatient eye review. It is a focused update on eligibility, evidence uncertainty and time-critical assessment in central retinal artery occlusion.

First-in-human prion disease research needs clear separation between symptomatic stabilisation and prevention in genetic-risk carriers. PRISM targets RNA encoding prion protein; the clinical point is to distinguish mechanism, population and aspiration from proven benefit.

Recurrent headache reviews need a treatment history that names what worked, partly worked or failed. Triptan choice, preventive therapy and AI-supported recommendations should sit beside broad history, prior response and red or amber features rather than default prescribing habits.

Developmental regression with loss of language, purposeful hand use or stereotyped hand movements should move quickly to paediatric neurology. MECP2 testing, early developmental therapies and multisystem monitoring matter, including epilepsy, gastrointestinal dysfunction, breathing abnormalities and orthopaedic complications.

Older adults asking whether shingles or RSV vaccination prevents dementia need cautious counselling. The reported lower dementia signal is observational and hypothesis-generating, so vaccine discussions should stay anchored to licensed indications while research explores the AS01 adjuvant.