The Neurology Minute® podcast delivers a brief daily summary of what you need to know in the field of neurology, the latest science focused on the brain, and timely topics explored by leading neurologists and neuroscientists. From the American Academy of Neurology and hosted by Stacey Clardy, MD, PhD, FAAN, with contributions by experts from the Neurology® journals, Neurology Today®, Continuum®, and more.
In the TEMPLE trial, atogepant causes fewer adverse-event-related discontinuations than topiramate (12% versus 30%) and achieves more 50% migraine-day responders (64% versus 39%). Improved preventive efficacy and tolerability must still be considered alongside serious adverse events.
Negative aquaporin-4 serology alone cannot establish seronegative neuromyelitis optica spectrum disorder. Additional clinical and MRI criteria are required. A referral study identifies frequent alternative diagnoses, particularly multiple sclerosis, and potential harm from unnecessary immunosuppression.
Epilepsy alone does not exclude menopausal hormonal therapy. Individualised counselling should identify symptoms that treatment may improve, consider interactions with antiseizure medicines and explain the limitations of the available evidence, supported by multidisciplinary decision-making.
A positive MOG-IgG result can mislead when pretest probability is low. TRUE-MOGAD combines clinical and MRI findings to support interpretation, but limitations in the studied populations and unrepresented presentations prevent its use as a standalone diagnostic test.
A small, non-randomised, unblinded comparison found lower neuropathy rates in compressed limbs during chemotherapy. Systematic assignment to non-dominant limbs and exclusion of pre-existing neuropathy limit confidence and generalisability.
Delusional misidentification can worsen with dopaminergic treatment in Parkinson's disease and dementia. Medication review, supportive caregiver responses and cautious consideration of antipsychotics must balance psychological distress against motor deterioration and neurological complications.
A birth-date eligibility cutoff for publicly funded shingles vaccination in Ontario creates a natural experiment for studying subsequent dementia. Comparing adults born close to the cutoff strengthens causal interpretation of protective signals without establishing that vaccination definitively prevents dementia.
Prior approval, patient cost sharing, medical debt and growing corporate involvement are presented as connected pressures on US healthcare. The speaker interprets these developments through a wider free-market policy shift rather than proposing specific clinical or policy interventions.
Delusional companion syndrome involves an unusually strong sense of familiarity with an inanimate object believed to think and feel. It occurs across neurological and psychiatric conditions, while proposed hemispheric mechanisms and right parietal localisation remain supported by limited evidence.
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