The Neurology Minute® podcast delivers a brief daily summary of what you need to know in the field of neurology, the latest science focused on the brain, and timely topics explored by leading neurologists and neuroscientists. From the American Academy of Neurology and hosted by Stacey Clardy, MD, PhD, FAAN, with contributions by experts from the Neurology® journals, Neurology Today®, Continuum®, and more.
A positive thyroid peroxidase antibody result establishes thyroid autoimmunity, not brain inflammation. The historical label of Hashimoto encephalopathy risks diagnostic closure and unnecessary immunotherapy unless the phenotype, alternative causes and objective treatment response are reassessed.
Borderline serum vitamin B12 should be interpreted alongside the neurological phenotype, absorption risks and renal function. Methylmalonic acid is the more specific functional marker, while homocysteine is supportive but can rise for several other reasons.
Cause-directed treatment for infantile epilepsy depends on whether the underlying problem is genetic or structural. Seizure freedom remains important, but developmental, cognitive and behavioural outcomes require long-term follow-up and should shape treatment evaluation.
Older adults may recover muscle strength and sensory function after spinal cord injury without equivalent gains in walking or personal care. Functional recovery declines more markedly around 70 years, but this is a change point rather than a fixed rehabilitation threshold.
Propensity-matched data from new neurology patients found no overall increase in 90-day follow-up, emergency department attendance, hospitalisation or testing after a virtual first visit. Small differences between presenting complaints support selective use and complaint-level monitoring rather than blanket conclusions
Rapid improvement with corticosteroids does not confirm Tolosa–Hunt syndrome. Painful ophthalmoplegia requires anatomical localisation with high-quality contrast MRI and a differential-led search for infection, malignancy, sarcoidosis, IgG4-related disease and other inflammatory causes.
Vamorolone shows similar reported motor improvement to traditional corticosteroids in Duchenne muscular dystrophy, with better height Z-scores suggesting less growth suppression. Cross-trial comparisons, differing cohorts and uncertain long-term significance prevent a claim of clinical superiority.
Infantile epilepsy should not be managed as a single disorder defined only by seizure frequency. Identifying the cause and classifying the electroclinical syndrome guide treatment; about two-thirds have epilepsy treatable with medication alone, while persistent seizures should prompt early consideration of specialised diets, surgery or other therapies.
Family history, an overall polygenic risk score and individual migraine-associated variants produce different findings after paediatric concussion. Family history is associated in two of five models, the overall score is not associated, and four of 40 variants are linked to increasing headache severity, supporting cautious interpretation rather than prediction.
A 4.5-point fall in Myasthenia Gravis Activities of Daily Living score with cemdisiran monotherapy is a within-group change; the placebo-adjusted effect is 2.3 points and meets the stated threshold for clinical meaning. The trial also challenges assumptions that combination C5 targeting must outperform monotherapy and keeps mechanism and safety interpretation proportionate.
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