October 25, 2026
The limits of a 24-hour alteplase window
Late alteplase improves one recovery measure but raises bleeding risk and leaves important timing questions unresolved.
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Critical Appraisal
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Critical Appraisal
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October 21, 2026
Two uncertainties behind unregulated peptide injections
Promising laboratory findings do not establish safe human use, particularly when injectable product quality is uncertain.
Read briefingOctober 20, 2026
Can simulation change an uncivil workplace?
Simulation can help teams rehearse difficult interactions, but reported benefits need careful interpretation.
Read briefingOctober 15, 2026
When the study answers the wrong question
GRADE helps distinguish promising research findings from evidence reliable enough to guide clinical decisions.
Read briefingOctober 14, 2026
A low cholesterol risk score can mislead
Lifetime lipid exposure, inherited markers and inflammatory disease can change prevention decisions despite reassuring results.
Read briefingOctober 10, 2026
Medical careers need more than another title
Mentoring, curiosity and personal priorities help clinicians decide which opportunities deserve their time.
Read briefingOctober 6, 2026
Crush injury needs tailored fluid resuscitation
Assess deficits, shock and mechanism before deciding how much fluid a patient with crush injury needs.
Read briefingOctober 5, 2026
Vasopressors need not wait for central access
A functioning short peripheral IV can start vasopressors promptly, provided the site is closely monitored.
Read briefingOctober 3, 2026
When chest pain still needs troponin
Atypical symptoms and absent risk factors do not reliably exclude myocardial infarction.
Read briefingOctober 1, 2026
Older abdominal pain needs a lower CT threshold
Minimal tenderness is less reassuring in older adults, so CT should remain readily considered.
Read briefingSeptember 30, 2026
ALS/NMD is a pattern, not a test
Mixed upper and lower motor neuron signs matter more than any single investigation when ALS is suspected.
Read briefingSeptember 27, 2026
The questions that expose clinical reasoning
Open “what” questions can uncover concerns and make clinical reasoning easier to examine.
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